日韩精品久久一区二区三区_亚洲色图p_亚洲综合在线最大成人_国产中出在线观看_日韩免费_亚洲综合在线一区

Global EditionASIA 中文雙語Fran?ais
World
Home / World / Americas

Stanford researchers relocate genes in cell with new gene-editing tool

Xinhua | Updated: 2018-10-12 01:31
Share
Share - WeChat
Stanley Qi and his team have developed a way to change the spatial organization of DNA in the nuclei of cells. This can allow scientists to determine how the spatial organization in the nucleus affects the overall function of a cell. 

WASHINGTON, Oct. 11 -- Researchers at Stanford University developed a new gene-editing technology to manipulate the genome in three-dimensional space, and found that genes behaved differently in different zones.

The study, published on Thursday in the journal Cell, showed that the new technique, dubbed CRISPR-GO, used a programmable guide RNA to ferry genetic snippets to different locations in a cell's nucleus, which was like a delivery system.

Displacing genetic elements can change how they function, according to the study.

"The question of why spatial organization in a cell matters is an important one, and it's also not one that scientists agree on," said Stanley Qi, assistant professor of bioengineering and of chemical and systems biology at Stanford.

"CRISPR-GO could provide an opportunity to answer that question by enabling us to target, move and relocate very specific stretches of DNA, and see how their new placements in the nucleus change how they function," said Qi, the paper's senior author.

Most mammalian cells contain a nucleus that houses more than 6 feet (about 183 cm) of DNA, if stretched out in a line. DNA tends to clump in certain areas in the nucleus but how that placement affects the DNA's function is no that clear.

In the new study, Qi and his colleague investigated three distinct sub-regions of the nucleus using CRISPR-GO, showing that specific compartments and some free-floating bodies of proteins in the nucleus can sway the function of repositioned DNA.

Depending on where the genetic materials are located, some nuclear regions repress gene expression and some accelerate telomere growth, and subsequently cell division, according to the study.

For example, the researchers observed that genes, relocated to a part of the nucleus called the Cajal body, an amorphic blob of proteins and RNA, stopped expressing proteins.

"It's the first time that researchers have evidence to show the Cajal body can have a direct gene-regulation effect, in this case repressing gene expression," Qi said.

Also, they used the tool to move the DNA of telomeres, the molecular caps of chromosomes that are associated with longevity, from the middle to the edge of the nucleus. Then the telomeres stopped growing, halting the cell cycle and reducing cell viability.

However, the opposite happened when telomeres were moved closer to the Cajal body. They grew and, in doing so, increased cell viability.

Qi hoped that one day, this line of research would come to bear on human health.

Most Viewed in 24 Hours
Top
BACK TO THE TOP
English
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
主站蜘蛛池模板: 国产xxxx搡xxxxx搡麻豆 | 人人干人人插 | 精品久久伊人 | 极品久久| 一级毛片免费播放 | 久草免费在线 | 小泽玛利亚一区二区 | 欧美激情人成日本在线视频 | 精产国产伦理一二三区 | 美女污直播 | 欧美日韩亚洲国内综合网俺 | 日本中文字幕电影 | 欧美成人精品一区二区男人看 | 久久久无码精品一区二区三区 | 五月婷婷开心综合 | 国产欧美一区二区三区精品 | 狠狠久 | 久草视频福利在线观看 | 国产精品爽爽va在线观看网站 | 成人爽a毛片在线视频网站 婷婷色在线观看 | 久久久久久久国产精品影院 | 午夜久久久久久久久久一区二区 | 日韩中文一区二区三区 | 成人在线网| av一区在线观看 | 黄视频欧美 | 色吧久久 | 日韩黄色大全 | 久久99热这里只频精品6中文字幕 | 欧美14一18处毛片 | 午夜不卡一区二区 | 亚洲国产欧美在线观看 | 久草草视频在线观看免费高清 | 97色在线| 国产精品13页 | 日本欧美不卡一区二区三区在线 | 欧美一级免费 | 午夜a狂野欧美一区二区 | 欧美激情免费观看一区 | 国产乱子伦一区二区三区 | 成人在线播放 |