日韩精品久久一区二区三区_亚洲色图p_亚洲综合在线最大成人_国产中出在线观看_日韩免费_亚洲综合在线一区

Global EditionASIA 中文雙語Fran?ais
Business
Home / Business / Companies

Filling gaps in drug development

By Liu Zhihua | China Daily | Updated: 2020-10-12 09:22
Share
Share - WeChat
An I-Mab employee performs tests at a lab in Shanghai in June. [Photo provided to China Daily]

I-Mab Biopharma accelerates worldwide expansion through R&D, licensing deals

I-Mab Biopharma, a Chinese drug developer, is accelerating its global expansion through research, development, manufacturing and commercial capabilities.

In its latest move, the company announced on Sept 4 it has inked a collaboration deal with AbbVie Inc, a US-based drugmaker. The deal, estimated to be worth more than $2.9 billion, gives AbbVie global out-licensing rights for cancer therapy lemzoparlimab.

I-Mab also announced that a consortium led by Hillhouse Capital has agreed to invest $418 million through a private placement.

Hillhouse Capital is a China-based investment firm known for dozens of successful startup investments like Tencent, JD, and Zoom.

The latest funding will be used to speed up clinical research at a global level and strengthen commercialization capabilities in China, I-Mab Biopharma said.

It plans to build a drug producing base in Hangzhou, capital of Zhejiang province, which will conform to good manufacturing practice or GMP standards. It will mark the company's transition to a whole-chain company from an R&D-heavy firm.

Founded by Zang Jingwu, a Chinese scientist, I-Mab said it wants to build a pipeline of highly differentiated, novel biologics with potential to address the significant unmet medical needs in cancer and autoimmune disorders worldwide.

Zang, who used to be the head of China R&D for GlaxoSmithKline, founded Third Venture Biopharma in 2015, which merged with Tasgen to become I-Mab in 2017.

The company was founded to capture the opportunities presented by the confluence of two major developments: the emergence of an attractive and growing biologics market in China, and revolutionary scientific breakthroughs in cancer and autoimmune diseases that are driving the development of new and innovative medicines, it said.

According to McKinsey and Co, a global management consulting firm, China's biopharma market continues to grow at a healthy pace, with total sales reaching some $130 billion in 2018, making China second only to the United States in world rankings.

As the country pursues innovation-driven high-quality development, Chinese biotech firms have also been adopting a stronger innovation mindset, conducting world-class scientific R&D, and developing cutting-edge treatments, industry experts said.

Such firms have also succeeded in developing several homegrown PD-1/PD-L1 inhibitors, a fiercely competitive field with potential to revolutionize cancer treatments and to help the human body's immune system to target and kill tumors.

They have also been able to out-license drug rights to international pharmaceutical leaders. Recent instances include Amgen signing a global collaboration for oncology drug development with BeiGene, and Lilly licensing a neutralizing antibody asset for COVID-19 from Junshi Biosciences.

Lemzoparlimab, also known as TJC4, is an anti-CD47 monoclonal antibody discovered by the Shanghai-based company to treat multiple forms of cancer.

It is widely seen as the company's ticket into a global race for the next class of promising cancer immunotherapies.

Anti-CD47 therapies represent one of the hottest areas in cancer drug development, which, through blocking CD47 function, target a "do-not-eat-me" signal that allows cancer cells to avoid being targeted by the patient's own immune system.

But the development of therapeutic CD47 antibodies has been hampered by hematologic side-effects, such as severe anemia, because of the binding of CD47 on red blood cells.

Lemzoparlimab is designed to minimize inherent binding to normal red blood cells while preserving its strong anti-tumor activity, a critical attribute in potentially differentiating lemzoparlimab from other antibodies of the same class currently in development, the company said.

Topline results of the recent phase 1 clinical trial in the US confirm possible differentiation of lemzoparlimab in drug safety and a more favorable pharmacokinetics profile in cancer patients.

The drug is paired with Merck Sharp& Dohme Corp's Keytruda for solid tumors and Biogen and Genentech's Rituxan for non-Hodgkin lymphoma in the ongoing US studies.

I-Mab is also planning to launch Phase 1/2 trials in China among patients with relapsed or refractory acute myeloid leukemia, or myelodysplastic syndrome. Results are expected in early 2021.

The Sept 4 deal gives AbbVie an exclusive global license, excluding the Chinese mainland, Hong Kong and Macao, to develop and commercialize lemzoparlimab.

AbbVie will pay I-Mab $180 million in an upfront payment, as well as $20 million in a milestone payment based on the Phase 1 results.

In addition, I-Mab will be eligible to receive up to $1.74 billion in success-based milestone payments, of which $840 million are based on clinical development and regulatory approval milestones, with the remainder based on commercial milestones.

Upon commercialization of lemzoparlimab, AbbVie will also pay tiered royalties from low-to-mid teen percentages on global net sales.

Importantly, I-Mab retains all rights to develop and commercialize lemzoparlimab in the Chinese mainland, Macao and Hong Kong, which is turning into a lucrative market for innovative medicines.

The two companies will share manufacturing responsibilities with Abb-Vie being the primary manufacturer for global supply. The collaboration will accelerate I-Mab's establishment of commercial production operations in China, the company said.

Thomas Hudson, senior vice-president of R&D and chief scientific officer, AbbVie, said in a statement that his company has been impressed with what I-Mab has been able to accomplish in research and clinical development and looks forward to working together to make a meaningful difference to the lives of millions of patients globally.

Zang, I-Mab's founder and honorary chairman, said the collaboration comes at a critical time, recognizes the R&D capabilities of the company, and will boost its collaboration with Big Pharma at home and abroad, to accelerate its global presence in new drug development and commercialization.

Trailing behind the development of a CD47 drug that has reached phase 3 study at clinical-stage immuno-oncology company Forty Seven Inc, which Gilead took over earlier this year, the Nasdaq-listed I-Mab has been reportedly looking for months for a powerful ally to speed up its own program.

"Through the new collaboration with AbbVie, we hope to quicken the development and commercialization of lemzoparlimab," Zang said.

"As similar collaborations are certain to follow, we are able to attract more capital to accelerate our R&D, to develop more new competitive biologics to go abroad, which will then form a virtuous circle for the company's development."

Top
BACK TO THE TOP
English
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
CLOSE
 
主站蜘蛛池模板: 尤物视频在线观看 | 久久久99精品久久久 | 97国产精品最新 | 成人久草 | 久草手机在线 | 婷婷在线网站 | 成人网18视频网站 | 日本黄色免费观看 | 国产免费www| 一本色道久久88综合亚洲精品高清 | 亚洲一区电影 | 性开放的欧美大片按摩 | 国产乱码精品一区二区三上 | www.五月婷 | 日韩av免费| 天天久久综合网站 | 成人精品一区二区三区校园激情 | 高清中文字幕免费观在线 | 日韩精品免费一级视频 | 日本一级特黄a大片在线 | 看一级毛片国产一级毛片 | 一区二区蜜桃 | 成人高清视频免费观看 | 欧美在线观看一区二区 | 在线视频综合视频免费观看 | 色狠狠婷婷97 | 波多野结衣99 | 国内精品免费视频 | 亚洲一区播放 | 丁香婷婷亚洲六月综合色 | 91精品欧美一区二区三区 | 上将的炮灰前妻重生了 | 天天操操 | 韩国男女无遮挡高清性视频 | 亚洲国语| 日韩精品不卡 | 国产精品久久久久久中文字 | 亚洲精品久久久久中文字幕二区 | 一二区视频| 天天草综合网 | 三级视频在线观看 |