SHANGHAI -- A Chinese research team has developed a multicellular scaffold based on inorganic bioceramics for treating tendon-to-bone injuries.

Restriction of motor activity due to loss of natural structure is a major cause of decreased life quality in patients suffering from tendon-to-bone injuries.

To solve this problem, the research team, led by the Shanghai Institute of Ceramics of the Chinese Academy of Sciences, combined manganese silicate nanoparticles with tendon/bone-related cells to construct an immunomodulatory multicellular scaffold to achieve integrated tendon-to-bone regeneration.

The scaffold not only demonstrated diverse biological activities in vitro, but also achieved immune regulation, multi-tissue integration regeneration and motor function recovery in a variety of animal models of rotator cuff injury.

The study provides a new concept for achieving immunomodulation and integrated regeneration of tendon-bone and other tissue interfaces, said Wu Chengtie with the SIC, who led the research.

The study was recently published in the journal Science Advances.