SYDNEY - Police are hunting for a gunman following a shooting which left two men dead in Sydney's west, local media reported on Friday.

Police and other emergency services were called to Boronia Street in the Sydney suburb of South Wentworthville at around 9:10 pm (local time) on Thursday after reports of gun shots, the New South Wales (NSW) Police Force said on Friday.

On arriving at the scene, police found a white ute crashed into another car in the front yard of a home and two men inside with multiple gunshot wounds.

Police believe the men, one aged in his early 20s and the other in his early 30s, were the victims of a targeted attack.

"What this is about is a specific targeted attack by people who knew each other, not someone who was shooting at houses without knowing who lives there," NSW Police Deputy Commissioner Nick Kaldas told the radio networks of the Australian Broadcasting Corporation (ABC Radio) on Friday.

Both men were treated by paramedics at the scene before being taken to Sydney's Westmead Hospital where they both later died, police said.

It was reported that a man approached the victims who were sitting in the ute and opened fire.

The driver tried to drive off but crashed into another vehicle in the front yard of a nearby home.